Logical modelling of gene regulatory networks with GINsim

Methods Mol Biol. 2012:804:463-79. doi: 10.1007/978-1-61779-361-5_23.


Discrete mathematical formalisms are well adapted to model large biological networks, for which detailed kinetic data are scarce. This chapter introduces the reader to a well-established qualitative (logical) framework for the modelling of regulatory networks. Relying on GINsim, a software implementing this logical formalism, we guide the reader step by step towards the definition and the analysis of a simple model of the lysis-lysogeny decision in the bacteriophage λ.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteriolysis / genetics
  • Bacteriophage lambda / genetics*
  • Gene Regulatory Networks / genetics*
  • Lysogeny / genetics
  • Mathematical Concepts
  • Models, Genetic*
  • Software*
  • Systems Biology / methods*