Impact of a collagen matrix on early healing, aesthetics and patient morbidity in oral mucosal wounds - a randomized study in humans

J Clin Periodontol. 2012 Feb;39(2):157-65. doi: 10.1111/j.1600-051X.2011.01823.x. Epub 2011 Dec 6.


Aim: To test whether a collagen matrix (CM) can improve early wound healing and aesthetics, and decrease wound sensitivity compared with spontaneous healing.

Methods: In 15 volunteers, 6-mm punch biopsies were harvested at both palatal sites. A CM was sutured in one site; the other one was left untreated (control). Measurements included the remaining defect area, the colour match to surrounding tissue and somatosensory parameters at various time-points (pre-operative, post-operative, 4, 8, 15, 29 days).

Results: The defect area decreased over time for both treatments. Re-epithelization was completed in all subjects by day 15. The defect area was significantly smaller for CM (mean ± SD: 19.3 ± 3.4 mm(2)) compared with control (21.3 ± 3.3 mm(2)) at day 4 (p < 0.05), and at day 8 (CM: 11.7 ± 2.5 mm(2) ; control: 13.6 ± 2.9 mm(2) ; p < 0.01). The colour match was more favourable for CM at day 4, 8 and 29 (p > 0.05). Somatosensory measurements revealed slightly lower wound sensitivity at day 4 for CM compared with control.

Conclusions: The use of CM can enhance wound healing compared with spontaneous healing during the first week. This was mainly documented by a faster re-epithelization. Colour match and wound sensitivity measurements did not reach statistical significance between CM and control sites.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorbable Implants*
  • Animals
  • Biocompatible Materials / therapeutic use*
  • Collagen / therapeutic use*
  • Humans
  • Mouth Mucosa / drug effects*
  • Mouth Mucosa / physiology
  • Mouth Mucosa / surgery
  • Oral Surgical Procedures / methods*
  • Palate / physiology
  • Palate / surgery
  • Patient Satisfaction
  • Swine
  • Transplantation, Heterologous
  • Treatment Outcome
  • Wound Healing / drug effects*


  • Biocompatible Materials
  • Collagen