The orbitofrontal cortex and response selection

Ann N Y Acad Sci. 2011 Dec;1239:25-32. doi: 10.1111/j.1749-6632.2011.06279.x.


Orbitofrontal cortex (OFC) function is often characterized in terms of stimulus-reward mapping; however, more recent evidence suggests that the OFC may play a role in selecting and representing extended actions. First, previously encoded reward associations in the OFC could be used to inform responding in novel but similar situations. Second, when evaluated in tasks requiring the animal to perform extended actions, response selective activity can be recorded in the OFC. Finally, the interaction between the OFC and hippocampus illustrates OFC's role in response selection. The OFC may facilitate reward-guided memory retrieval by selecting the memories most relevant to achieve a goal. This model for OFC function places it within the hierarchy of increasingly complex action representations that support decision making.

Publication types

  • Review

MeSH terms

  • Animals
  • Behavior, Animal
  • Brain Mapping*
  • Decision Making
  • Frontal Lobe / physiology*
  • Hippocampus / physiology
  • Humans
  • Memory*
  • Models, Psychological
  • Neurons / physiology*
  • Physiology, Comparative / methods
  • Reversal Learning
  • Reward