Predictors for tubercular uveitis: a comparison between biopsy-proven cases of tubercular and sarcoid uveitis

Retina. 2012 May;32(5):1017-20. doi: 10.1097/IAE.0b013e31822d3a20.

Abstract

Aim: To look for clinical parameters that will assist in making a diagnosis of tubercular or sarcoid uveitis in a South Indian patient population

Methods: Retrospective, nonrandomized, comparative study of 51 patients with a diagnosis of biopsy-proven tuberculosis and sarcoidosis. These patients had a minimum of 1-year follow-up after initiating treatment for either disease. Multivariate logistic regression analysis was used to determine clinical predictors of tubercular uveitis.

Results: The mean age group was 47.08 ± 11.19 years. There were 39 women and 12 men in the study. Multivariate logistic regression analysis shows likelihood of uveitis being tubercular in etiology using 3 variables: Schirmer test >10 mm, retinal vasculitis with areas of multiple, pigmented chorioretinal atrophy along blood vessels, and a positive Mantoux test 76.6%.

Conclusion: A combination of Schirmer test >10 mm, retinal vasculitis with areas of multiple, pigmented chorioretinal atrophy along blood vessels, and positive Mantoux test may be used clinically to differentiate tubercular from sarcoid uveitis in our patient population.

Publication types

  • Comparative Study

MeSH terms

  • Biopsy
  • Corneal Dystrophies, Hereditary / diagnosis
  • Diagnosis, Differential
  • Diagnostic Techniques, Ophthalmological
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retinal Vasculitis / diagnosis
  • Retrospective Studies
  • Sarcoidosis / diagnosis*
  • Tears / metabolism
  • Tuberculin Test
  • Tuberculosis, Ocular / diagnosis*
  • Uveitis / diagnosis*

Supplementary concepts

  • Chorioretinal atrophy, progressive bifocal