Studies of methylhexaneamine in supplements and geranium oil

Drug Test Anal. 2011 Nov-Dec;3(11-12):873-6. doi: 10.1002/dta.392. Epub 2011 Dec 6.


A number of supplements are now available which are sold as fat burners or pre-workout boosters and contain stimulants which are banned in sport. Many contain methylhexaneamine under one of many pseudonyms including Geranamine, geranium oil or extract, or a number of chemical names such as 1,3-dimethylpentylamine. This has resulted in many athletes returning an adverse finding and having sanctions imposed. Other stimulants such as caffeine, phenpromethamine, synefrine, and phenethylamines are also to be found in supplements. This communication shows that geranium oils do not contain methylhexaneamine and that products labelled as containing geranium oil but which contain methylhexaneamine can only arise from the addition of synthetic material. Since the usual dose of methylhexaneamine is large, the drug is excreted at relatively high amounts for more than 29 h, the time for which the excretion was studied.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / analysis*
  • Amines / urine
  • Central Nervous System Stimulants / analysis*
  • Dietary Supplements / analysis*
  • Geranium / chemistry*
  • Humans
  • Plant Oils / analysis*
  • Substance Abuse Detection / methods


  • Amines
  • Central Nervous System Stimulants
  • Plant Oils
  • methylhexaneamine