Roles of hydrogen sulfide in the pathogenesis of diabetes mellitus and its complications

Antioxid Redox Signal. 2012 Jul 1;17(1):68-80. doi: 10.1089/ars.2011.4451. Epub 2012 Jan 30.

Abstract

Significance: Diabetes and its complications represent a major socioeconomic problem.

Recent advances: Changes in the balance of hydrogen sulfide (H(2)S) play an important role in the pathogenesis of β-cell dysfunction that occurs in response to type 1 and type 2 diabetes. In addition, changes in H(2)S homeostasis also play a role in the pathogenesis of endothelial injury, which develop on the basis of chronically or intermittently elevated circulating glucose levels in diabetes.

Critical issues: In the first part of this review, experimental evidence is summarized implicating H(2)S overproduction as a causative factor in the pathogenesis of β-cell death in diabetes. In the second part of our review, experimental evidence is presented supporting the role of H(2)S deficiency (as a result of increased H(2)S consumption by hyperglycemic cells) in the pathogenesis of diabetic endothelial dysfunction, diabetic nephropathy, and cardiomyopathy.

Future directions: In the final section of the review, future research directions and potential experimental therapeutic approaches around the pharmacological modulation of H(2)S homeostasis in diabetes are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Diabetes Complications / metabolism*
  • Diabetes Mellitus / metabolism*
  • Humans
  • Hydrogen Sulfide / metabolism*

Substances

  • Hydrogen Sulfide