Gluten sensitivity: problems of an emerging condition separate from celiac disease

Expert Rev Gastroenterol Hepatol. 2012 Feb;6(1):43-55. doi: 10.1586/egh.11.79.


Gluten sensitivity appears to be emerging as a separate condition from celiac disease, yet no clear definition or diagnosis exists. As a result, patients with gluten sensitivity experience delayed diagnosis and continuing symptoms if they consume gluten. This emerging medical problem may involve human genetics, plant genetic modifications, gluten as a food additive, environmental toxins, hormonal influences, intestinal infections and autoimmune diseases. The treatment is similar to that for celiac disease - a gluten-free diet. The use of a gluten-free diet or an elimination diet is encouraged in assisting people to determine whether or not they are gluten sensitive. It is time to not only recognize, but to treat and further research gluten sensitivity, as unconfirmed environmental factors continue to spread this problem further into the general population.

Publication types

  • Review

MeSH terms

  • Autoimmune Diseases / diagnosis
  • Breeding
  • Celiac Disease / diagnosis*
  • Diagnosis, Differential
  • Diet, Gluten-Free
  • Food Hypersensitivity / diagnosis*
  • Glutens / adverse effects*
  • Humans
  • Triticum / adverse effects
  • Triticum / immunology
  • Wheat Hypersensitivity / diagnosis*


  • Glutens