Rhodium(III)-catalyzed intermolecular direct amination of aromatic C-H bonds with N-chloroamines

Ka-Ho Ng; Zhongyuan Zhou; Wing-Yiu Yu

doi:10.1021/ol203046n

Rhodium(III)-catalyzed intermolecular direct amination of aromatic C-H bonds with N-chloroamines

Org Lett. 2012 Jan 6;14(1):272-5. doi: 10.1021/ol203046n. Epub 2011 Dec 13.

Authors

Ka-Ho Ng¹, Zhongyuan Zhou, Wing-Yiu Yu

Affiliation

¹ State Key Laboratory for Chirosciences and The Open Laboratory for Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong.

PMID: 22149646
DOI: 10.1021/ol203046n

Abstract

A Rh(III)-catalyzed direct aromatic C-H amination is achieved using N-chloroamines as a reagent. Furthermore, we also developed a one-pot amination protocol involving in situ chlorination of the secondary amines. The catalytic amination operates at mild conditions with excellent functional group tolerance and regioselectivity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amination
Carbon / chemistry*
Catalysis
Chloramines / chemistry*
Hydrogen / chemistry*
Molecular Structure
Rhodium / chemistry*

Substances

Chloramines
Carbon
Hydrogen
Rhodium