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Meta-Analysis
. 2011 Dec 12;12:159.
doi: 10.1186/1471-2350-12-159.

The Insertion/Deletion (I/D) Polymorphism in the Angiotensin-converting Enzyme Gene and Cancer Risk: A Meta-Analysis

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Free PMC article
Meta-Analysis

The Insertion/Deletion (I/D) Polymorphism in the Angiotensin-converting Enzyme Gene and Cancer Risk: A Meta-Analysis

Yonggang Zhang et al. BMC Med Genet. .
Free PMC article

Abstract

Background: The insertion/deletion (I/D) polymorphism in the Angiotensin-converting enzyme (ACE) gene has been implicated in susceptibility to cancer, but a large number of studies have reported inconclusive results. The aim of this study is to assess the association between the I/D polymorphism in the ACE gene and cancer risk by meta-analysis.

Methods: A search was performed in Pubmed database, Embase database, Chinese Biomedical (CBM) database, China National Knowledge Infrastructure (CNKI) database and Weipu database, covering all studies until August 31, 2010. Statistical analysis was performed by using Revman4.2 and STATA 10.0.

Results: A total of 25 case-control studies comprising 3914 cancer patients and 11391 controls were identified. No significant association was found between the I/D polymorphism and over all cancer risks (OR = 0.88, 95%CI = 0.73-1.06, P = 0.17 for DD+DI vs. II). In the subgroup analysis by ethnicity, no significant association was found among Asians and Europeans for the comparison of DD+DI vs. II. In the subgroup analysis by cancer types, no significant associations were found among lung cancer, breast cancer, prostate cancer, colorectal cancer, gastric cancer for the comparison of DD+DI vs. II. Results from other comparative genetic models also indicated the lack of associations between this polymorphism and cancer risks.

Conclusions: This meta-analysis suggested that the ACE D/I polymorphism might not contribute to the risk of cancer.

Figures

Figure 1
Figure 1
Flow diagram of included/excluded studies.
Figure 2
Figure 2
Meta-analysis with a random-effects model for the association between cancer risk and the ACE I/D polymorphism (DD+DI vs II).
Figure 3
Figure 3
Meta-analysis with a random-effects model for the association between cancer risk and the ACE I/D polymorphism (DD+DI vs II): subgroup analysis by ethnicity.
Figure 4
Figure 4
Meta-analysis with a random-effects model for the association between cancer risk and the ACE I/D polymorphism (DD+DI vs II): subgroup analysis by cancer type.
Figure 5
Figure 5
Begg's funnel plot for publication bias in selection of studies on the ACE I/D polymorphism (DD+DI vs II).

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