Weaving the web of ER tubules

Cell. 2011 Dec 9;147(6):1226-31. doi: 10.1016/j.cell.2011.11.022.


How is the characteristic shape of an organelle generated? Recent work has provided insight into how the tubular network of the endoplasmic reticulum (ER) is formed. The tubules themselves are shaped by the reticulons and DP1/Yop1p, whereas their fusion into a network is brought about by membrane-bound GTPases that include the atlastins, Sey1p, and RHD3.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytoskeleton / metabolism
  • Endoplasmic Reticulum / metabolism*
  • GTP-Binding Proteins / metabolism
  • Humans
  • Membrane Proteins / metabolism
  • Organelles / metabolism
  • Plant Cells / metabolism
  • Vertebrates
  • Yeasts / metabolism


  • Membrane Proteins
  • GTP-Binding Proteins