Crashpilot underachieves due to acetylation at the nerve terminal

Ruud F Toonen; Matthijs Verhage

doi:10.1016/j.neuron.2011.11.008

Crashpilot underachieves due to acetylation at the nerve terminal

Neuron. 2011 Dec 8;72(5):679-81. doi: 10.1016/j.neuron.2011.11.008.

Authors

Ruud F Toonen¹, Matthijs Verhage

Affiliation

¹ Department of Functional Genomics, Center for Neurogenomics and Cognitive Neuroscience, Neuroscience Campus Amsterdam, VU University and VU Medical Center, 1081HV Amsterdam, The Netherlands.

PMID: 22153363
DOI: 10.1016/j.neuron.2011.11.008

Abstract

Protein acetylation is mostly known for its role in chromatin remodeling. In this issue, Miśkiewicz and colleagues reveal a novel function of acetylation at the nerve terminal, where it regulates T bars and the number of associated synaptic vesicles to ultimately control the efficacy of synaptic transmission.

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