Persistent pupillary membrane, strabismus, and optic nerve hypoplasia in Donnai-Barrow syndrome

J AAPOS. 2011 Dec;15(6):604-5. doi: 10.1016/j.jaapos.2011.07.016.

Abstract

We report a case of Donnai-Barrow syndrome in a 2-year-old boy who presented with exotropia and prominent eyes since birth. Ocular findings included high myopia, persistent pupillary membrane, and optic nerve hypoplasia. Facial manifestations included broad nasal bridge, hypertelorism, and downward-slanting of palpebral fissures. The patient had associated omphalocele, sensorineural hearing loss, and developmental delay. Magnetic resonance imaging revealed agenesis of the corpus callosum. To our knowledge, this is the first reported association of persistent pupillary membrane, strabismus, and optic nerve hypoplasia in a patient with Donnai-Barrow syndrome.

Publication types

  • Case Reports

MeSH terms

  • Agenesis of Corpus Callosum / complications*
  • Child, Preschool
  • Exotropia / diagnosis*
  • Hearing Loss, Sensorineural / complications*
  • Hernias, Diaphragmatic, Congenital
  • Humans
  • Male
  • Myopia / complications*
  • Optic Nerve / abnormalities*
  • Proteinuria / complications*
  • Pupil Disorders / diagnosis*
  • Renal Tubular Transport, Inborn Errors

Supplementary concepts

  • Donnai-Barrow syndrome