Structural organization of the kinetochore-microtubule interface

Curr Opin Cell Biol. 2012 Feb;24(1):48-56. doi: 10.1016/ Epub 2011 Dec 10.


Successful mitosis depends on the stable, yet regulated attachment of chromosomes to spindle microtubules. The kinetochore, a large macromolecular structure assembled at sites of centromeric heterochromatin, is responsible for generating and regulating these essential attachments. Over the last several years, concerted experimental efforts have brought the structural view of the kinetochore-microtubule interface more clearly into focus. Here, we review important recent advancements and discuss several unresolved questions regarding how kinetochores dynamically bridge mitotic chromosomes to spindle microtubules.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chromosomes / chemistry
  • Chromosomes / metabolism
  • Humans
  • Kinetochores / chemistry*
  • Kinetochores / metabolism*
  • Microtubules / chemistry*
  • Microtubules / metabolism*
  • Mitosis
  • Spindle Apparatus / chemistry
  • Spindle Apparatus / metabolism