Cohesin and chromatin organisation

Curr Opin Genet Dev. 2012 Apr;22(2):93-100. doi: 10.1016/j.gde.2011.11.003. Epub 2011 Dec 10.

Abstract

Cohesin defines the topology of chromosomes in mitosis and meiosis by holding sister chromatids together; more recently a role for cohesin in chromatin organisation and gene expression in interphase has emerged.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / metabolism*
  • Chromatin* / chemistry
  • Chromatin* / metabolism
  • Chromosomal Proteins, Non-Histone / metabolism*
  • DNA Replication
  • Gene Expression
  • Humans
  • Interphase
  • Transcription, Genetic

Substances

  • Cell Cycle Proteins
  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • cohesins