Sensitivity of Salmonella Typhimurium YG1024 to Urine Mutagenicity Caused by Cigarette Smoking

Mutat Res. 1990 Oct;245(2):87-92. doi: 10.1016/0165-7992(90)90005-5.

Abstract

Salmonella typhimurium YG1024, an O-acetyltransferase-overproducing derivative of TA98, was found to be more sensitive in detecting mutagenicity in human urine caused by cigarette smoking, than the conventional strain TA98, in Ames test in the presence of S9 mix. YG1021, another derivative of TA98 with elevated nitroreductase levels, did not show increased sensitivity. These results suggest that the mutagenic compounds concentrated by Blue Rayon from smokers' urine are aromatic amino compounds.

MeSH terms

  • Animals
  • Biotransformation
  • Humans
  • Male
  • Microsomes, Liver / metabolism
  • Mutagenicity Tests
  • Mutagens / pharmacology
  • Reference Values
  • Salmonella typhimurium / genetics*
  • Smoking / urine*

Substances

  • Mutagens