Management of the clotting system: a European perspective

Curr Opin Anaesthesiol. 2012 Feb;25(1):80-5. doi: 10.1097/ACO.0b013e32834ef3d1.


Purpose of review: Coagulation management remains a challenge for anesthesiologists involved in cardiovascular surgery as the population undergoing surgery becomes older and presents with more comorbidities. These patients are frequently treated with one or more agents that directly affect coagulation. This review will discuss what is known and the treatments available to manage coagulation in the perioperative setting of cardiac surgery.

Recent findings: New antithrombotics will be discussed as well as their proposed substitution in the preoperative period. The review will also describe the different products available in Europe for the treatment of bleeding and coagulopathy. Finally, the use of new monitoring devices will be discussed.

Summary: The introduction of new drugs with different mechanisms of action adds to the complexity of coagulation management during cardiovascular surgery. Monitoring needs to be developed and improved, especially for evaluating platelet function.

Publication types

  • Review

MeSH terms

  • Anticoagulants / therapeutic use
  • Blood Coagulation Disorders / therapy*
  • Blood Loss, Surgical / prevention & control
  • Cardiac Surgical Procedures*
  • Cardiovascular Diseases / therapy
  • Erythrocyte Transfusion
  • Europe
  • Hemorrhage / therapy*
  • Hemostasis
  • Humans
  • Plasma
  • Preoperative Care*


  • Anticoagulants