This randomized, double-blind, placebo-controlled, multicenter clinical study investigated the efficacy and various safety aspects of a standardized proprietary isopropanolic extract of black cohosh (Remifemin) in a population of 304 postmenopausal women who met strict parameter guidelines that determined the inclusion criteria. This clinical study confirmed previous results, which clearly indicate the efficacy and tolerability of this proprietary black cohosh extract (Remifemin) in addressing menopausal symptoms, particularly hot flashes.