We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2 in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo replication analysis (12,284 cases and 13,172 controls). The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3. GLIS3, which is involved in pancreatic beta cell development and insulin gene expression, is known for its association with fasting glucose levels. The evidence of an association with T2D for PEPD and HNF4A has been shown in previous studies. KCNK16 may regulate glucose-dependent insulin secretion in the pancreas. These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D.
Assessing variation across 8 established East Asian loci for type 2 diabetes mellitus in American Indians: Suggestive evidence for new sex-specific diabetes signals in GLIS3 and ZFAND3.Diabetes Metab Res Rev. 2017 May;33(4). doi: 10.1002/dmrr.2869. Epub 2016 Dec 28. Diabetes Metab Res Rev. 2017. PMID: 27862917
Replication study for the association of 9 East Asian GWAS-derived loci with susceptibility to type 2 diabetes in a Japanese population.PLoS One. 2013 Sep 25;8(9):e76317. doi: 10.1371/journal.pone.0076317. eCollection 2013. PLoS One. 2013. PMID: 24086726 Free PMC article.
East Asian Genome-wide association study derived loci in relation to type 2 diabetes in the Han Chinese population.Acta Biochim Pol. 2019 May 30;66(2):159-165. doi: 10.18388/abp.2018_2632. Acta Biochim Pol. 2019. PMID: 31145772
Population specific impact of genetic variants in KCNJ11 gene to type 2 diabetes: a case-control and meta-analysis study.PLoS One. 2014 Sep 23;9(9):e107021. doi: 10.1371/journal.pone.0107021. eCollection 2014. PLoS One. 2014. PMID: 25247988 Free PMC article. Review.
Genetics of type 2 diabetes in East Asian populations.Curr Diab Rep. 2012 Dec;12(6):686-96. doi: 10.1007/s11892-012-0326-z. Curr Diab Rep. 2012. PMID: 22993124 Review.
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