Purinergic signaling in healthy and diseased skin

J Invest Dermatol. 2012 Mar;132(3 Pt 1):526-46. doi: 10.1038/jid.2011.344. Epub 2011 Dec 8.

Abstract

Adenosine 5'-triphosphate and adenosine receptors have been identified in adult and fetal keratinocytes, fibroblasts, melanocytes, mast cells, Langerhans cells, and Meissner's corpuscles, as well as in hair follicles, sweat glands, and smooth muscle and endothelial cells of skin vessels. Purinergic signaling is involved in skin pathology, including inflammation, wound healing, pain, psoriasis, scleroderma, warts, and skin cancer.

Publication types

  • Review

MeSH terms

  • Adenosine Diphosphate / metabolism*
  • Adenosine Triphosphate / metabolism*
  • Animals
  • Female
  • Humans
  • Male
  • Mice
  • Purinergic Agonists / pharmacology
  • Purinergic Antagonists / pharmacology
  • Rats
  • Receptors, Purinergic P1 / metabolism*
  • Receptors, Purinergic P2 / metabolism*
  • Signal Transduction
  • Skin / metabolism*
  • Skin / pathology
  • Skin Diseases / metabolism*
  • Skin Diseases / pathology

Substances

  • Purinergic Agonists
  • Purinergic Antagonists
  • Receptors, Purinergic P1
  • Receptors, Purinergic P2
  • Adenosine Diphosphate
  • Adenosine Triphosphate