Cortical high-gamma responses in auditory processing

Am J Audiol. 2011 Dec;20(2):171-80. doi: 10.1044/1059-0889(2011/10-0036).


Purpose: This tutorial provides an introduction to cortical auditory spectral responses, focusing on event-related activity in the high-gamma frequencies (60-150 Hz), their recent emergence in neuroscience research, and potential clinical applications.

Method: Auditory high-gamma responses are described and compared with traditional cortical evoked responses, including the auditory evoked N1 response. Methods for acquiring and analyzing spectral responses, including time-frequency analyses, are discussed and contrasted with more familiar time-domain averaging approaches. Four cases are presented illustrating high-gamma response patterns associated with normal and impaired auditory processing.

Conclusions: Cortical auditory high-gamma responses may provide a useful clinical measure of auditory processing.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Auditory Cortex / physiology*
  • Education, Medical, Continuing
  • Electroencephalography
  • Epilepsy / complications
  • Epilepsy / physiopathology
  • Evoked Potentials, Auditory / physiology*
  • Female
  • Humans
  • Language Development Disorders / diagnosis*
  • Language Development Disorders / etiology
  • Language Development Disorders / physiopathology*
  • Male
  • Young Adult