Genetics and molecular epidemiology of multiple myeloma: the rationale for the IMMEnSE consortium (review)

Int J Oncol. 2012 Mar;40(3):625-38. doi: 10.3892/ijo.2011.1284. Epub 2011 Dec 6.


There is strong evidence suggesting the presence of a genetic component in the aetiology of multiple myeloma (MM). However no genetic risk factors have been unequivocally established so far. To further our understanding of the genetic determinants of MM risk, a promising strategy is to collect a large set of patients in a consortium, as successfully done for other cancers. In this article, we review the main findings in the genetic susceptibility and pharmacogenetics of MM and present the strategy of the IMMEnSE (International Multiple Myeloma rESEarch) consortium in contributing to determine the role of genetic variation in pharmacogenetics and in MM risk.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Genetic Predisposition to Disease
  • Genetic Variation
  • Humans
  • Molecular Epidemiology / methods
  • Multiple Myeloma / epidemiology*
  • Multiple Myeloma / genetics*
  • Pharmacogenetics / methods
  • Risk Factors