Combined effect of antioxidant supplementation and resistance training on oxidative stress markers, muscle and body composition in an elderly population

J Nutr Health Aging. 2011 Dec;15(10):883-9. doi: 10.1007/s12603-011-0097-2.


This study was aimed to examine the effect of vitamin C/E intake alone or combined with resistance training on antioxidant/pro-oxidant status, muscle strength and body composition in an elderly population. Fifty-seven men and women with a mean age of 65.6 ± 3.8 years were recruited and randomized in a double-blind fashion into four groups: control-placebo; resistance training (RT); vitamins C/E supplementation (AS); AS+RT. Oxidative stress status and metabolic and lipid profiles were determined at baseline and after six months. Fat-free mass and fat mass measured by DXA were similar at baseline for all groups. At six month, there was a significant difference among the groups as a function of vitamin E supplementation. Moreover, although there was no effect on pro-oxidative parameters, a significant effect on body composition was noted, but no difference was noted on strength gain. The combination of RT+AS had a positive effect on the plasma antioxidant profile but not on the pro-oxidant status.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorptiometry, Photon
  • Adipose Tissue / drug effects
  • Aged
  • Antioxidants / metabolism
  • Antioxidants / pharmacology*
  • Ascorbic Acid / pharmacology*
  • Biomarkers
  • Body Composition* / drug effects
  • Body Fluid Compartments / drug effects
  • Dietary Supplements
  • Double-Blind Method
  • Female
  • Geriatric Assessment
  • Humans
  • Male
  • Middle Aged
  • Muscle Strength / drug effects
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / physiology*
  • Oxidative Stress* / drug effects
  • Resistance Training*
  • Vitamin E / pharmacology*


  • Antioxidants
  • Biomarkers
  • Vitamin E
  • Ascorbic Acid