New triterpenoids from the leaves of Cyclocarya paliurus

Planta Med. 2012 Feb;78(3):290-6. doi: 10.1055/s-0031-1280411. Epub 2011 Dec 7.

Abstract

Six new triterpenoids including four new secodammarane triterpenoid glycosides (1-4), an epoxydammarane triterpenoid glycoside (5), and a new secodammarane triterpenoid (6) were isolated from the ethanolic extract of the leaves of Cyclocarya paliurus. The structures of these compounds were elucidated by spectroscopic analysis methods. Compounds 1-6 were evaluated for their inhibitory activities against α-glucosidase, lipase, DPP-IV, and aldose reductase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehyde Reductase / antagonists & inhibitors
  • Aldehyde Reductase / metabolism
  • China
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology
  • Glycoside Hydrolase Inhibitors
  • Glycosides / isolation & purification
  • Glycosides / pharmacology
  • Juglandaceae / chemistry*
  • Lipase / antagonists & inhibitors
  • Lipase / metabolism
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plant Leaves / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology*
  • alpha-Glucosidases / metabolism

Substances

  • Enzyme Inhibitors
  • Glycoside Hydrolase Inhibitors
  • Glycosides
  • Plant Extracts
  • Triterpenes
  • Aldehyde Reductase
  • Lipase
  • alpha-Glucosidases