Effect of microRNA-34a in Cell Cycle, Differentiation, and Apoptosis: A Review

J Biochem Mol Toxicol. 2012 Feb;26(2):79-86. doi: 10.1002/jbt.20412. Epub 2011 Dec 12.

Abstract

The tumor suppressor gene p53 was shown to directly regulate the expression of microRNA-34a (miR-34a). miR-34a regulates a plethora of target proteins, which are involved in cell cycle, apoptosis, differentiation, and cellular development.miR-34a resides in the region of chromosome 1p36.23, which is commonly deleted in many tumor types, while it results in the loss expression of miR-34a. The promoters of the miR-34a gene subject to inactivation by CpG methylation also induce the loss expression of miR-34a. Ectopic miR-34a expression induces apoptosis, cell cycle arrest, and differentiation or reduces migration. This review summarizes the progress regarding the role of miR-34a in cell cycle, differentiation, and apoptosis.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibody-Dependent Cell Cytotoxicity
  • Apoptosis*
  • Base Sequence
  • Cell Cycle*
  • Cell Differentiation*
  • Gene Expression Regulation
  • Humans
  • MicroRNAs / genetics
  • MicroRNAs / metabolism
  • MicroRNAs / physiology*
  • Molecular Sequence Data
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • RNA Interference

Substances

  • MIRN34 microRNA, human
  • MicroRNAs