Occupational risk factors and pancreatic cancer: a review of recent findings

Mol Carcinog. 2012 Jan;51(1):98-108. doi: 10.1002/mc.20779.


Several occupational exposures have been linked to excess risk of pancreatic cancer; however, most associations are not well established. The objective of this review article is to report on the more recently published studies (1998-2010), and provide a summary of the most consistently reported occupational risk factors for pancreatic cancer, including exposure to chlorinated hydrocarbon compounds, pesticides, polycyclic aromatic hydrocarbons (PAHs), metals, nitrosamines, radiation, various airborne particles, and employment in sedentary occupations. We conclude that the strongest and most consistent findings linking occupational exposures with pancreatic cancer risk to date are for chlorinated hydrocarbons and PAHs.

Publication types

  • Review

MeSH terms

  • Humans
  • Hydrocarbons, Chlorinated / toxicity*
  • Nitrosamines / toxicity
  • Occupational Exposure*
  • Pancreatic Neoplasms / chemically induced
  • Pancreatic Neoplasms / epidemiology*
  • Pancreatic Neoplasms / etiology*
  • Particulate Matter / toxicity
  • Pesticides / toxicity
  • Polycyclic Aromatic Hydrocarbons / toxicity*
  • Risk Factors
  • Sedentary Behavior


  • Hydrocarbons, Chlorinated
  • Nitrosamines
  • Particulate Matter
  • Pesticides
  • Polycyclic Aromatic Hydrocarbons