Strong correlation between liver and serum levels of hepatitis C virus core antigen and RNA in chronically infected patients

J Clin Microbiol. 2012 Feb;50(2):465-8. doi: 10.1128/JCM.06503-11. Epub 2011 Dec 7.


HCV core antigen (Ag) and HCV RNA levels were evaluated in matched liver biopsy samples and sera from 22 patients with hepatitis C infection by using the quantitative Architect HCV Ag immunoassay and a real-time RT-qPCR assay, respectively. The data showed a strong correlation between liver and serum compartments of HCV Ag levels (r = 0.80) and HCV RNA levels (r = 0.87). In summary, the serum HCV Ag and RNA levels reflect the intrahepatic values.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biopsy
  • Female
  • Hepacivirus / isolation & purification*
  • Hepatitis C, Chronic / virology*
  • Humans
  • Immunoassay
  • Liver / virology*
  • Male
  • Middle Aged
  • RNA, Viral / analysis*
  • Real-Time Polymerase Chain Reaction
  • Reverse Transcriptase Polymerase Chain Reaction
  • Serum / virology*
  • Statistics as Topic
  • Viral Core Proteins / analysis*


  • RNA, Viral
  • Viral Core Proteins
  • nucleocapsid protein, Hepatitis C virus