Possible involvement of tight junctions, extracellular matrix and nuclear receptors in epithelial differentiation

J Biomed Biotechnol. 2011;2011:253048. doi: 10.1155/2011/253048. Epub 2011 Nov 17.

Abstract

Tight junctions are intercellular junctions localized at the most apical end of the lateral plasma membrane. They consist of four kinds of transmembrane proteins (occludin, claudins, junctional adhesion molecules, and tricellulin) and huge numbers of scaffolding proteins and contribute to the paracellular barrier and fence function. The mutation and deletion of these proteins impair the functions of tight junctions and cause various human diseases. In this paper, we provide an overview of recent studies on transmembrane proteins of tight junctions and highlight the functional significance of tight junctions, extracellular matrix, and nuclear receptors in epithelial differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Adhesion Molecules / genetics
  • Cell Adhesion Molecules / metabolism
  • Cell Differentiation
  • Claudins / genetics
  • Claudins / metabolism
  • Epithelial Cells / cytology*
  • Extracellular Matrix / metabolism*
  • Gene Deletion
  • Humans
  • Junctional Adhesion Molecules
  • MARVEL Domain Containing 2 Protein
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Mutation / genetics
  • Occludin
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Tight Junctions / metabolism*

Substances

  • Cell Adhesion Molecules
  • Claudins
  • Junctional Adhesion Molecules
  • MARVEL Domain Containing 2 Protein
  • MARVELD2 protein, human
  • Membrane Proteins
  • OCLN protein, human
  • Occludin
  • Receptors, Cytoplasmic and Nuclear