Cost effectiveness of fibrosis assessment prior to treatment for chronic hepatitis C patients

PLoS One. 2011;6(12):e26783. doi: 10.1371/journal.pone.0026783. Epub 2011 Dec 2.


Background and aims: Chronic hepatitis C (HCV) is a liver disease affecting over 3 million Americans. Liver biopsy is the gold standard for assessing liver fibrosis and is used as a benchmark for initiating treatment, though it is expensive and carries risks of complications. FibroTest is a non-invasive biomarker assay for fibrosis, proposed as a screening alternative to biopsy.

Methods: We assessed the cost-effectiveness of FibroTest and liver biopsy used alone or sequentially for six strategies followed by treatment of eligible U.S. patients: FibroTest only; FibroTest with liver biopsy for ambiguous results; FibroTest followed by biopsy to rule in; or to rule out significant fibrosis; biopsy only (recommended practice); and treatment without screening. We developed a Markov model of chronic HCV that tracks fibrosis progression. Outcomes were expressed as expected lifetime costs (2009 USD), quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICER).

Results: Treatment of chronic HCV without fibrosis screening is preferred for both men and women. For genotype 1 patients treated with pegylated interferon and ribavirin, the ICERs are $5,400/QALY (men) and $6,300/QALY (women) compared to FibroTest only; the ICERs increase to $27,200/QALY (men) and $30,000/QALY (women) with the addition of telaprevir. For genotypes 2 and 3, treatment is more effective and less costly than all alternatives. In clinical settings where testing is required prior to treatment, FibroTest only is more effective and less costly than liver biopsy. These results are robust to multi-way and probabilistic sensitivity analyses.

Conclusions: Early treatment of chronic HCV is superior to the other fibrosis screening strategies. In clinical settings where testing is required, FibroTest screening is a cost-effective alternative to liver biopsy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Algorithms
  • Antiviral Agents / economics
  • Antiviral Agents / therapeutic use
  • Biomarkers / metabolism
  • Biopsy / methods
  • Cost-Benefit Analysis*
  • Disease Progression
  • Female
  • Fibrosis / economics*
  • Fibrosis / metabolism
  • Fibrosis / therapy*
  • Genotype
  • Hepatitis C, Chronic / economics*
  • Hepatitis C, Chronic / therapy*
  • Humans
  • Liver / pathology
  • Male
  • Markov Chains
  • Middle Aged
  • Probability
  • Quality-Adjusted Life Years
  • Risk Assessment


  • Antiviral Agents
  • Biomarkers