tyk2, prototype of a novel class of non-receptor tyrosine kinase genes

Oncogene. 1990 Sep;5(9):1329-36.


We previously identified a novel protein tyrosine kinase gene, tyk2, by screening a human lymphoid cDNA library with a tyrosine kinase domain specific c-fms restriction fragment under low stringency hybridization conditions. We have now isolated and sequenced a full length tyk2 cDNA clone; demonstrated that this gene is widely expressed in hematopoietic and non-hematopoietic cell lines; and mapped it to chromosome 19p13.2. The cDNA clone is 4176 nucleotides long and codes for a putative protein with a molecular weight of 134 kilodaltons. Hydrophobicity analysis of our sequence does not identify a transmembrane domain, which is found in all members of the receptor class of protein tyrosine kinases; nor can we detect an SH2 domain, found in all previously identified non-receptor protein kinases. We therefore propose that tyk2 is the prototype of a new class of non-receptor protein tyrosine kinases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Blotting, Northern
  • Chromosome Mapping
  • Chromosomes, Human, Pair 19 / chemistry*
  • DNA / analysis
  • Gene Library
  • Humans
  • Molecular Sequence Data
  • Protein-Tyrosine Kinases / genetics*
  • RNA, Messenger / genetics*
  • Repetitive Sequences, Nucleic Acid


  • RNA, Messenger
  • DNA
  • Protein-Tyrosine Kinases

Associated data

  • GENBANK/X54637