Effects of metal coverage rate of flow diversion device on neointimal growth at side branch ostium and stented artery: an animal experiment in rabbit abdominal aorta

Neuroradiology. 2012 Aug;54(8):849-55. doi: 10.1007/s00234-011-0984-6. Epub 2011 Dec 15.


Introduction: To access the effect of actual metal coverage rate (MCR) on neointimal growth at covered side branch ostium and stented artery after implantation of a flow diversion device.

Methods: Flow diverters (FDs) were implanted into abdominal aortas of 20 New Zealand rabbits. Four weeks and three months after FD implantation, the patency of side branches covered by the devices was assessed by angiography. The animals were sacrificed after angiography at 3 months postsurgery. The local actual MCR was measured under microscope and calculated. The extent of neointimal coverage at the ostia of branches and the neointima within the stent were examined by histology and scanning electron microscopy.

Results: No side branch occlusion was noted, either immediately after implantation or at follow-ups. At 3 months after implantation, the intimal coverage of branch ostia caused by a 30-40% MCR was not significantly different from that caused by an MCR ≤ 30% (p = 0.792), but it was significantly lower than that caused by an MCR ≥ 40% (p = 0.021). Neointimal thickness in the stented abdominal aorta was positively correlated to MCR (r = 0.523, p = 0.001). The neointima was composed predominantly of smooth muscle cells and collagen fibers.

Conclusion: The actual MCR exhibited remarkable differences once FD was implanted in vivo. Significantly more intimal coverage at the side branch ostia could be induced when MCR was ≥40%. The neointimal thickness within the stent was positively correlated to device MCR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiography
  • Animals
  • Aorta, Abdominal / pathology*
  • Aorta, Abdominal / surgery
  • Linear Models
  • Metals
  • Microscopy, Electron, Scanning
  • Models, Animal
  • Neointima / pathology*
  • Rabbits
  • Stents*
  • Vascular Patency*


  • Metals