The key to halting progression of CKD might be in the produce market, not in the pharmacy

Kidney Int. 2012 Jan;81(1):7-9. doi: 10.1038/ki.2011.331.


In vitro, experimental, and clinical work suggests that metabolic acidosis, either directly or indirectly, can promote the progression of chronic kidney disease (CKD). Goraya et al. demonstrate that both oral alkali supplementation and a diet rich in fruits and vegetables are equally effective at decreasing urinary excretion of markers of renal injury in patients with stage 2 CKD. Although this study is promising, the short duration and use of only urinary markers as a surrogate outcome weaken the conclusions.

Publication types

  • Comment

MeSH terms

  • Acids / antagonists & inhibitors*
  • Diet*
  • Female
  • Humans
  • Hypertension / complications*
  • Kidney Diseases / diet therapy*
  • Kidney Diseases / etiology*
  • Male


  • Acids