Immune Correlates of Herpes Zoster in HIV-infected Children and Youth

J Virol. 2012 Mar;86(5):2878-81. doi: 10.1128/JVI.06623-11. Epub 2011 Dec 14.

Abstract

To identify immunologic factors that modulate the risk of herpes zoster (HZ), we compared varicella-zoster virus (VZV)-specific and nonspecific T-cell subpopulations of 47 HIV-infected children before they developed HZ with those of 141 VZV-positive HZ-negative matched controls. Compared with controls, HZ cases had lower VZV-specific CD8(+) CD107a(+) cell percentages independently of CD4(+) percentages or HIV loads, suggesting that VZV-specific cytotoxic T cells are protective against HZ. In contrast, high nonspecific regulatory and activated T cells were associated with an increased risk of HZ.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • HIV Infections / complications*
  • HIV Infections / immunology
  • HIV Infections / virology
  • Herpes Zoster / etiology
  • Herpes Zoster / immunology*
  • Herpes Zoster / virology
  • Herpesvirus 3, Human / immunology*
  • Herpesvirus 3, Human / physiology
  • Humans
  • Male
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / virology
  • T-Lymphocytes, Cytotoxic / immunology
  • T-Lymphocytes, Cytotoxic / virology
  • Young Adult