Aspirin and immune system

Int Immunopharmacol. 2012 Jan;12(1):10-20. doi: 10.1016/j.intimp.2011.11.021. Epub 2011 Dec 13.


The time-tested gradual exploration of aspirin's diverse pharmacological properties has made it the most reliable therapeutic agent worldwide. In addition to its well-argued anti-inflammatory effects, many new and exciting data have emerged regarding the role of aspirin in cells of the immune system and certain immunopathological states. For instance, aspirin induces tolerogenic activity in dendritic cells and determines the fate of naive T cells to regulatory phenotypes, which suggests its immunoregulatory potential in relevance to immune tolerance. It also displays some intriguing traits to modulate the innate and adaptive immune responses. In this article, the immunomodulatory relation of aspirin to different immune cells, such as neutrophils, macrophages, dendritic cells (DCs), natural killer (NK) cells, and the T and B lymphocytes has been highlighted. Moreover, the clinical prospects of aspirin in terms of autoimmunity, allograft rejection and immune tolerance have also been outlined.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Aspirin / pharmacology*
  • Aspirin / therapeutic use
  • Autoimmune Diseases / drug therapy
  • Autoimmune Diseases / immunology
  • Dendritic Cells / drug effects
  • Dendritic Cells / immunology
  • Graft Rejection / immunology
  • Graft Rejection / prevention & control
  • Humans
  • Immune Tolerance / drug effects
  • Immunologic Factors / pharmacology*
  • Immunologic Factors / therapeutic use
  • Inflammation / drug therapy
  • Inflammation / immunology
  • Leukocytes / drug effects
  • Leukocytes / immunology
  • Macrophages / drug effects
  • Macrophages / immunology


  • Anti-Inflammatory Agents, Non-Steroidal
  • Immunologic Factors
  • Aspirin