Alternative path to EMT: regulation of apicobasal polarity in Drosophila

Dev Cell. 2011 Dec 13;21(6):983-4. doi: 10.1016/j.devcel.2011.11.017.


The epithelial-to-mesenchymal transition (EMT), a key process in morphogenesis, is often driven by repressing expression of adherens junction components, such as E-cadherin. In this issue of Developmental Cell, Campbell et al. (2011) uncover an alternative mechanism in the Drosophila embryonic gut that promotes EMT via Serpent, a GATA transcriptional repressor of the apicobasal polarity gene crumbs.

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