First isolation of Tropheryma whipplei from bronchoalveolar fluid and clinical implications

J Infect. 2012 Sep;65(3):275-8. doi: 10.1016/j.jinf.2011.11.026. Epub 2011 Dec 4.


A patient presented diffuse pulmonary parenchymal micronodules. Tropheryma whipplei was detected in the saliva, a bronchial biopsy and bronchoalveolar fluid. PAS staining, immunohistochemistry and PCR for T. whipplei were negative in the duodenal biopsies. T. whipplei was isolated from the bronchoalveolar fluid, reinforcing its role as a respiratory pathogen.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Bronchoalveolar Lavage Fluid / microbiology*
  • Female
  • Humans
  • Pneumonia, Bacterial / diagnosis
  • Pneumonia, Bacterial / microbiology*
  • Tropheryma / genetics
  • Tropheryma / isolation & purification*
  • Whipple Disease / diagnosis
  • Whipple Disease / microbiology*