Effect of Ginkgo leaf parenteral solution on blood and cochlea antioxidant and immunity indexes in OM rats

Molecules. 2011 Dec 15;16(12):10433-42. doi: 10.3390/molecules161210433.


Oxidative stress is involved in the development and progression of otitis media (OM). In this study, we investigated the effect of Ginkgo leaf parenteral solution on blood and cochlea antioxidant and immunity indexs in OM rats. In OM model rats, blood and cochlea malondialdehyde (MDA), nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) levels were significantly increased, whereas antioxidant enzymes activities (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GR)) were significantly decreased compared with normal rats. Treatment with Ginkgo leaf parenteral solution restored the altered parameters in a dose-dependent manner. We conclude that Ginkgo leaf parenteral solution confers protection against oxidative injuries in OM rats by increasing activities of antioxidants and immunity, suggesting a potential drug for the prevention and therapy of OM.

MeSH terms

  • Animals
  • Antioxidants / metabolism*
  • Catalase / blood
  • Cochlea / drug effects
  • Cochlea / enzymology
  • Cochlea / immunology*
  • Ginkgo biloba / chemistry*
  • Glutathione / blood
  • Immunity / drug effects*
  • Infusions, Parenteral
  • Male
  • Malondialdehyde / blood
  • Otitis Media / blood*
  • Otitis Media / drug therapy
  • Otitis Media / immunology
  • Phytotherapy
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plant Leaves / chemistry*
  • Rats
  • Rats, Wistar
  • Superoxide Dismutase / blood


  • Antioxidants
  • Plant Extracts
  • Malondialdehyde
  • Catalase
  • Superoxide Dismutase
  • Glutathione