The use of bone grafts and bone graft substitutes in pediatric orthopaedics: an overview

J Pediatr Orthop. Jan-Feb 2012;32(1):100-5. doi: 10.1097/BPO.0b013e31823d8350.


Bone graft substitutes have become progressively more widely used, and are currently heavily marketed. To make intelligent decisions, a complete knowledge of autograaft and allograft bone healing is essential, including the definition of "sterile". Differences in donor selection and tissue processing may confound the user not familiar with the implications of these different approaches. Specific products include demineralized bone matrix (DBM), specific growth factors (recombinant BMP's), ceramic grafts, and platelet-rich plasma (PRP). There are a number of useful applications of bone graft substitues for pediatric orthopaedists, but the data base is evolving. This paper describes the current status of these products.

MeSH terms

  • Bone Substitutes / therapeutic use*
  • Bone Transplantation / methods*
  • Child
  • Donor Selection
  • Humans
  • Orthopedic Procedures / methods*
  • Pediatrics
  • Tissue Donors
  • Tissue and Organ Harvesting / methods
  • Transplantation, Autologous / methods
  • Transplantation, Homologous / methods


  • Bone Substitutes