Cancer chemoprevention by citrus pulp and juices containing high amounts of β-cryptoxanthin and hesperidin

J Biomed Biotechnol. 2012;2012:516981. doi: 10.1155/2012/516981. Epub 2011 Nov 24.


β-Cryptoxanthin, a carotenoid, and hesperidin, a flavonoid, possess inhibitory effects on carcinogenesis in several tissues. We recently have prepared a pulp (CHRP) and citrus juices (MJ2 and MJ5) from a satsuma mandarin (Citrus unshiu Mar.) juice (MJ). They contain high amounts of β-cryptoxanthin and hesperidin. We have demonstrated that CHRP and/or MJs inhibit chemically induced rat colon, rat tongue, and mouse lung tumorigenesis. Gavage with CHRP resulted in an increase of activities of detoxifying enzymes in the liver, colon, and tongue rats'. CHRP and MJs were also able to suppress the expression of proinflammatory cytokines and inflammatory enzymes in the target tissues. This paper describes the findings of our in vivo preclinical experiments to develop a strategy for cancer chemoprevention of colon, tongue, and lung neoplasms by use of CHRP and MJs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animal Feed
  • Animals
  • Anticarcinogenic Agents / pharmacology
  • Beverages
  • Cell Line, Tumor
  • Citrus / metabolism*
  • Colonic Neoplasms / prevention & control*
  • Cryptoxanthins
  • Cytokines / metabolism
  • Hesperidin / pharmacology*
  • Humans
  • Inflammation
  • Lung Neoplasms / prevention & control*
  • Mice
  • Models, Chemical
  • Neoplasm Transplantation
  • Rats
  • Rats, Inbred F344
  • Tongue Neoplasms / prevention & control*
  • Xanthophylls / pharmacology*


  • Anticarcinogenic Agents
  • Cryptoxanthins
  • Cytokines
  • Xanthophylls
  • Hesperidin