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Case Reports
, 5, 1667-71

Wide-field Fundus Autofluorescence Corresponds to Visual Fields in Chorioretinitis Patients

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Case Reports

Wide-field Fundus Autofluorescence Corresponds to Visual Fields in Chorioretinitis Patients

Florian Seidensticker et al. Clin Ophthalmol.

Abstract

Background and objectives: Detection of peripheral fundus autofluorescence (FAF) using conventional scanning laser ophthalmoscopes (SLOs) is difficult and requires pupil dilation. Here we evaluated the diagnostic properties of wide-field FAF detected by a two-laser wavelength wide-field SLO in uveitis patients.

Study design/materials and methods: Observational case series of four patients suffering from different types of posterior uveitis/chorioretinitis. Wide-field FAF images were compared to visual fields. Panretinal FAF was detected by a newly developed SLO, which allows FAF imaging of up to 200° of the retina in one scan without the need for pupil dilation. Visual fields were obtained by Goldmann manual perimetry.

Results: Findings from wide-field FAF imaging showed correspondence to visual field defects in all cases.

Conclusion: Wide-field FAF allowed the detection of visual field defect-related alterations of the retinal pigment epithelium in all four uveitis cases.

Keywords: Optomap; fundus autofluorescence (FAF); imaging; uveitis; visual field; wide-field scanning laser ophthalmoscopy.

Figures

Figure 1
Figure 1
Case 1: (A, B, C, and D) Optomap color fundus imaging (A and B) and wide-field FAF (C and D) of the right (A and C) and left eye (B and D). (E and F) corresponding visual fields measured with Goldmann manual perimetry. The nasal paracentral scotoma of the right eye, and the large scotoma extending from the blind spot nasally on the left eye correspond well with the areas of reduced FAF. Abbreviation: FAF, fundus autofluorescence.
Figure 2
Figure 2
Case 2: (A and B) Optomap color fundus imaging (A) and wide-field FAF (B) of the right eye. (C) Corresponding visual field measured with Goldmann manual perimetry. Abbreviation: FAF, fundus autofluorescence.
Figure 3
Figure 3
Case 3: (A, B, C, and D) Optomap color imaging (A and B), wide-field FAF (C and D) of the right and left eye, and corresponding visual fields (E and F). In both eyes peripapillary arc-shaped areas of hypofluorescence extending from the central pole, surrounded by hyperfluorescent borders can be seen in Optomap FAF (C and D). Abbreviation: FAF, fundus autofluorescence.
Figure 4
Figure 4
Case 4: (A, B, C, and D) Optomap color imaging (A and B), wide-field FAF (C and D) of the right eye and left, and corresponding visual fields (E and F). In both eyes, pigmented scars at the posterior pole and the periphery can be seen in Optomap color fundus imaging. FAF reveals distinct serpiginous and geographic areas of reduced FAF in both eyes. These findings correspond to visual field defects found in Goldmann perimetry. Abbreviation: FAF, fundus autofluorescence.

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References

    1. Schmitz-Valckenberg S, Bültmann S, Dreyhaupt J, Bindewald A, Holz FG, Rohrschneider K. Fundus autofluorescence and fundus perimetry in the junctional zone of geographic atrophy in patients with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2004;45(12):4470–4476. - PubMed
    1. Kernt M, Schaller UC, Stumpf C, Ulbig MW, Kampik A, Neubauer AS. Choroidal pigmented lesions imaged by ultra-wide-field scanning laser ophthalmoscopy with two laser wavelengths (Optomap) Clin Ophthalmol. 2010;4:829–836. - PMC - PubMed
    1. Hammer M, Königsdörffer E, Liebermann C, et al. Ocular fundus autofluorescence observations at different wavelengths in patients with age-related macular degeneration and diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 2008;246(1):105–114. - PubMed
    1. Schweitzer D, Schenke S, Hammer M, et al. Towards metabolic mapping of the human retina. Microsc Res Tech. 2007;70(5):410–419. - PubMed
    1. Boon CJ, Jeroen Klevering B, Keunen JE, Hoyng CB, Theelen T. Fundus autofluorescence imaging of retinal dystrophies. Vision Res. 2008;48(26):2569–2577. - PubMed

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