Sexual dysfunction in women with ketamine cystitis: a case-control study

BJU Int. 2012 Aug;110(3):427-31. doi: 10.1111/j.1464-410X.2011.10780.x. Epub 2011 Dec 16.


Objective: • To conduct a case-control study evaluating clinical symptom severity and sexual dysfunction in women with ketamine cystitis (KC).

Patients and methods: • In total, 29 patients with KC and 27 controls completed the symptoms survey. • Participants completed a visual pelvic pain analogue scale, an O'Leary-Sant Interstitial Cystitis Symptom Index and Problem Index questionnaire, a Female Sexual Function Index, and a short form of the Chinese Health Questionnaire-12.

Results: • Both the Interstitial Cystitis Symptom Index and Interstitial Cystitis Problem Index scores were significantly higher in patients with KC compared to controls (P < 0.001). • The prevalence of sexual dysfunction was high in patients with KC. • There was a difference in total adjusted Female Sexual Function Index scores between the patients with KC and controls: mean (sd) total Female Sexual Function Index score 17.65 (6.15) for KC cases vs 25.87 (4.16) for controls (P < 0.001). • Except for the sexual desire domain of female sexual dysfunction, patients with KC scored lower on all domains compared to controls. • There was no significant difference between patients with KC and controls with respect to mental health as evaluated by the Chinese Health Questionnaire-12.

Conclusions: • Sexual dysfunction and KC symptoms severely impacted on quality of life. • Mental health had no significant difference between patients with KC and controls.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Cross-Sectional Studies
  • Cystitis, Interstitial / chemically induced*
  • Excitatory Amino Acid Antagonists / toxicity*
  • Female
  • Humans
  • Ketamine / toxicity*
  • Sexual Dysfunction, Physiological / chemically induced*
  • Substance-Related Disorders / complications*
  • Young Adult


  • Excitatory Amino Acid Antagonists
  • Ketamine