Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics Part I. The molecular basis of scar formation

J Am Acad Dermatol. 2012 Jan;66(1):1-10; quiz 11-2. doi: 10.1016/j.jaad.2011.05.055.

Abstract

Cutaneous scarring is often the epicenter of patient-related concerns, and the question "Will there be a scar?" is one that is all too familiar to the everyday clinician. In approaching this topic, we have reviewed the pathology, the embryology, and the molecular biology of cutaneous scarring.

Publication types

  • Review

MeSH terms

  • Animals
  • Cicatrix / pathology
  • Cicatrix / physiopathology*
  • Cicatrix / prevention & control
  • Early Growth Response Protein 1 / physiology
  • Granulation Tissue / physiology
  • Granulation Tissue / physiopathology
  • Homeodomain Proteins / physiology
  • Humans
  • Inflammation Mediators / physiology
  • Platelet-Derived Growth Factor / physiology
  • Signal Transduction
  • Skin / pathology
  • Skin / physiopathology*
  • Transforming Growth Factors / physiology
  • Wnt Signaling Pathway
  • Wound Healing / physiology*

Substances

  • Early Growth Response Protein 1
  • HOXB13 protein, human
  • Homeodomain Proteins
  • Inflammation Mediators
  • Platelet-Derived Growth Factor
  • Transforming Growth Factors