Structure, assembly and reading of centromeric chromatin

Curr Opin Genet Dev. 2012 Apr;22(2):139-47. doi: 10.1016/j.gde.2011.11.005. Epub 2011 Dec 16.


Centromeres are epigenetically defined chromatin domains marked by the presence of the histone H3 variant CENP-A. Here we review recent structural and biochemical work on CENP-A, and advances in understanding the mechanisms that propagate and read centromeric chromatin domains.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoantigens / chemistry*
  • Autoantigens / metabolism*
  • Centromere Protein A
  • Centromere*
  • Chromatin*
  • Chromosomal Proteins, Non-Histone / chemistry*
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Humans
  • Protein Binding


  • Autoantigens
  • CENPA protein, human
  • Centromere Protein A
  • Chromatin
  • Chromosomal Proteins, Non-Histone