Erythrocyte and Reticulocyte Binding-Like Proteins of Plasmodium Falciparum

Trends Parasitol. 2012 Jan;28(1):23-30. doi: 10.1016/j.pt.2011.10.002. Epub 2011 Dec 16.

Abstract

The global agenda for malaria eradication would benefit from development of a highly efficacious vaccine that protects against disease and interrupts transmission of Plasmodium falciparum. It is likely that such a vaccine will be multi-component, with antigens from different stages of the parasite life cycle. In this review, inclusion of blood stage antigens in such a vaccine is discussed. Erythrocyte binding-like (EBL) and P. falciparum reticulocyte binding-like (PfRh) proteins are reviewed with respect to their function in erythrocyte invasion, their role in eliciting antibodies contributing to protective immunity and reduction of invasion, leading subsequently to inhibition of parasite multiplication.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Erythrocytes / immunology
  • Erythrocytes / metabolism
  • Erythrocytes / parasitology
  • Humans
  • Life Cycle Stages / immunology
  • Malaria Vaccines / immunology*
  • Malaria Vaccines / metabolism
  • Malaria, Falciparum / prevention & control*
  • Plasmodium falciparum / immunology*
  • Plasmodium falciparum / metabolism
  • Plasmodium falciparum / pathogenicity
  • Protozoan Proteins / immunology*
  • Protozoan Proteins / metabolism
  • Reticulocytes / immunology
  • Reticulocytes / metabolism

Substances

  • Malaria Vaccines
  • Protozoan Proteins