Eucommia ulmoides bark protects against renal injury in cadmium-challenged rats

J Med Food. 2012 Mar;15(3):307-14. doi: 10.1089/jmf.2011.1756. Epub 2011 Dec 19.

Abstract

Eucommia ulmoides Oliver is a perennial woody plant distributed widely in China. To characterize some major compounds in E. ulmoides bark extract, six compounds were identified via high-performance liquid chromatography qualitative analysis. E. ulmoides bark extract protects against cadmium-induced oxidative damage in rat kidneys. Two compounds of E. ulmoides bark extract, geniposide and genipin, which were identified both in serum and in kidney tissue, showed inhibitory effects on nitric oxide production. This study provides biological evidence supporting the usefulness of E. ulmoides bark against cadmium-induced toxic oxidative stress in rat kidney tissue.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / analysis
  • Anti-Inflammatory Agents, Non-Steroidal / blood
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Cadmium Poisoning / drug therapy*
  • Cadmium Poisoning / metabolism
  • Cadmium Poisoning / pathology
  • Cadmium Poisoning / physiopathology
  • Drug Discovery
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / therapeutic use*
  • Eucommiaceae / chemistry*
  • Iridoids / analysis
  • Iridoids / blood
  • Iridoids / pharmacokinetics
  • Iridoids / pharmacology
  • Kidney / drug effects
  • Kidney / metabolism
  • Kidney / pathology
  • Kidney / physiopathology
  • Macrophage Activation / drug effects
  • Male
  • Mice
  • Mice, Inbred Strains
  • Nitric Oxide / metabolism
  • Oxidative Stress / drug effects
  • Plant Bark / chemistry*
  • Protective Agents / chemistry
  • Protective Agents / therapeutic use*
  • Rats
  • Rats, Sprague-Dawley
  • Renal Insufficiency / etiology
  • Renal Insufficiency / prevention & control*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Drugs, Chinese Herbal
  • Iridoids
  • Protective Agents
  • geniposide
  • Nitric Oxide
  • genipin