Association between vitamin D receptor polymorphisms and periodontitis: a meta-analysis

J Periodontol. 2012 Sep;83(9):1095-103. doi: 10.1902/jop.2011.110518. Epub 2011 Dec 19.


Background: The purpose of the meta-analysis is to explore the association between vitamin D receptor polymorphisms (including four gene loci: Taq-I, Bsm-I, Apa-I, and Fok-I) for susceptibility to periodontitis (either chronic [CP] or aggressive [AP]). Up to now, there has been only one systematic review focusing on this topic. We obtained some different findings compared with the previously published literature.

Methods: Nineteen case-control studies were identified through a search of multiple electronic databases (from January 1, 1999 to June 30, 2011). The pooled odds ratios (ORs) and 95% confidence intervals (CIs) using codominant, dominant, and recessive genetic models from meta-analysis were the main outcome measure. The Harbord test was used to detect the publication bias for each group.

Results: Eighteen identified articles met the eligibility criteria. Through overall analyses, no statistical association was found between polymorphisms of the four gene loci and periodontitis. However, based on subgroup analyses, a significant association between the Taq-I variants and CP rather than AP was shown in Asians (OR = 0.590; 95% CI = 0.425, 0.818) but not in whites (OR = 0.823; 95% CI = 0.637, 1.063). No statistically significant association was found between polymorphisms of Bsm-I and Apa-I with either AP or CP. The Fok-I polymorphism showed a statistical association with AP (OR = 1.583; 95% CI = 1.157, 2.166) instead of CP (OR = 1.081; 95% CI = 0.638, 1.830) in Asians.

Conclusions: The results of the present meta-analysis indicate the following: 1) the mutant allele t of the Taq-I locus may be a protective factor for CP but not for AP in Asians, although this was not true in whites; 2) the mutant allele F of the Fok-I locus appeared to be a risk factor for AP rather than CP in Asians; and 3) Bsm-I and Apa-I polymorphisms were found to have no significant associations with susceptibility to periodontitis (CP/AP).

Publication types

  • Comparative Study
  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Aggressive Periodontitis / genetics
  • Alleles
  • Asian Continental Ancestry Group / genetics
  • Case-Control Studies
  • Chromosome Mapping
  • Chronic Periodontitis / genetics
  • Deoxyribonucleases, Type II Site-Specific / genetics
  • European Continental Ancestry Group / genetics
  • Genes, Dominant / genetics
  • Genes, Recessive / genetics
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Mutation / genetics
  • Periodontitis / genetics*
  • Polymorphism, Genetic / genetics*
  • Receptors, Calcitriol / genetics*
  • Risk Factors
  • Thymine


  • Receptors, Calcitriol
  • endodeoxyribonuclease BsmI
  • endodeoxyribonuclease FokI
  • Deoxyribonucleases, Type II Site-Specific
  • GGGCCC-specific type II deoxyribonucleases
  • TCGA-specific type II deoxyribonucleases
  • Thymine