IQGAP1 and its binding proteins control diverse biological functions

Cell Signal. 2012 Apr;24(4):826-34. doi: 10.1016/j.cellsig.2011.12.005. Epub 2011 Dec 11.

Abstract

IQGAP proteins have been identified in a wide spectrum of organisms, ranging from yeast to humans. The most extensively studied family member is the ubiquitously expressed scaffold protein IQGAP1, which participates in multiple essential aspects of mammalian biology. IQGAP1 mediates these effects by binding to and regulating the function of numerous interacting proteins. Over ninety proteins have been reported to associate with IQGAP1, either directly or as part of a larger complex. In this review, we summarise those IQGAP1 binding partners that have been identified in the last five years. The molecular mechanisms by which these interactions contribute to the functions of receptors and their signalling cascades, small GTPase function, cytoskeletal dynamics, neuronal regulation and intracellular trafficking are evaluated. The evidence that has accumulated recently validates the role of IQGAP1 as a scaffold protein and expands the repertoire of cellular activities in which it participates.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Actins / genetics
  • Actins / metabolism
  • Adherens Junctions / genetics
  • Adherens Junctions / metabolism
  • Animals
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Cell Movement
  • Cytoskeleton / genetics
  • Cytoskeleton / metabolism*
  • Gene Expression Regulation*
  • Humans
  • Mice
  • Microtubules / genetics
  • Microtubules / metabolism
  • Mitogen-Activated Protein Kinase Kinases / genetics
  • Mitogen-Activated Protein Kinase Kinases / metabolism
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Phosphatidylinositol 3-Kinases / genetics
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phosphorylation
  • Protein Binding
  • Protein Interaction Mapping
  • Protein Transport / genetics
  • Proto-Oncogene Proteins c-akt / genetics
  • Proto-Oncogene Proteins c-akt / metabolism
  • Receptor Protein-Tyrosine Kinases
  • Receptors, Chemokine / genetics
  • Receptors, Chemokine / metabolism
  • Signal Transduction / genetics*
  • ras GTPase-Activating Proteins* / genetics
  • ras GTPase-Activating Proteins* / metabolism

Substances

  • Actins
  • Carrier Proteins
  • IQ motif containing GTPase activating protein 1
  • Nuclear Proteins
  • Receptors, Chemokine
  • ras GTPase-Activating Proteins
  • Phosphatidylinositol 3-Kinases
  • Receptor Protein-Tyrosine Kinases
  • Proto-Oncogene Proteins c-akt
  • Mitogen-Activated Protein Kinase Kinases