Type 1 diabetes mellitus in 2011: Heterogeneity of T1DM raises questions for therapy

Paolo Pozzilli

doi:10.1038/nrendo.2011.228

Type 1 diabetes mellitus in 2011: Heterogeneity of T1DM raises questions for therapy

Nat Rev Endocrinol. 2011 Dec 20;8(2):78-80. doi: 10.1038/nrendo.2011.228.

Author

Paolo Pozzilli¹

Affiliation

¹ Department of Endocrinology and Diabetes, University Campus Bio-Medico, Via Álvaro del Portillo, 21, 00128 Rome, Italy. p.pozzilli@unicampus.it

PMID: 22183128
DOI: 10.1038/nrendo.2011.228

Abstract

Research in 2011 regarding β-cell destruction, early immunointervention trials and development of late complications in type 1 diabetes mellitus have highlighted the heterogeneity of this disease. Patient phenotyping should be performed for the implementation of tailored therapies, especially taking into account the age at which the disease is diagnosed.

Publication types

Review

MeSH terms

Animals
Diabetes Mellitus, Type 1 / epidemiology
Diabetes Mellitus, Type 1 / genetics*
Diabetes Mellitus, Type 1 / immunology
Diabetes Mellitus, Type 1 / therapy*
Endocrinology / methods
Endocrinology / trends*
Genetic Heterogeneity*
Humans
Immunophenotyping / methods
Mice
Molecular Targeted Therapy / methods
Molecular Targeted Therapy / trends
Time Factors