The dependence of viral RNA replication on co-opted host factors

Nat Rev Microbiol. 2011 Dec 19;10(2):137-49. doi: 10.1038/nrmicro2692.


Positive-sense RNA ((+)RNA) viruses such as hepatitis C virus exploit host cells by subverting host proteins, remodelling subcellular membranes, co-opting and modulating protein and ribonucleoprotein complexes, and altering cellular metabolic pathways during infection. To facilitate RNA replication, (+)RNA viruses interact with numerous host molecules through protein-protein, RNA-protein and protein-lipid interactions. These interactions lead to the formation of viral replication complexes, which produce new viral RNA progeny in host cells. This Review presents the recent progress that has been made in understanding the role of co-opted host proteins and membranes during (+)RNA virus replication, and discusses common themes employed by different viruses.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Coronavirus / physiology
  • Flavivirus / physiology
  • Humans
  • Integration Host Factors / physiology
  • Molecular Chaperones / physiology
  • Poliomyelitis / virology
  • Poliovirus / physiology
  • RNA Virus Infections / genetics
  • RNA Virus Infections / virology
  • RNA Viruses / physiology*
  • RNA, Viral / metabolism*
  • Saccharomyces cerevisiae / virology
  • Virus Replication / physiology*


  • Integration Host Factors
  • Molecular Chaperones
  • RNA, Viral