Neisseria gonorrhoeae with high-level resistance to azithromycin: case report of the first isolate identified in the United States

Clin Infect Dis. 2012 Mar;54(6):841-3. doi: 10.1093/cid/cir929. Epub 2011 Dec 19.


We report on the first Neisseria gonorrhoeae isolate in the United States identified with high-level resistance to azithromycin. This report discusses the epidemiologic case investigation, the molecular studies of resistance-associated mutations and N. gonorrhoeae multiantigen sequence typing, and challenges posed by emerging gonococcal antimicrobial resistance.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology*
  • Azithromycin / pharmacology*
  • Drug Resistance, Bacterial*
  • Female
  • Gonorrhea / microbiology*
  • Hawaii
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Neisseria gonorrhoeae / drug effects*
  • Neisseria gonorrhoeae / genetics
  • Neisseria gonorrhoeae / immunology
  • Young Adult


  • Anti-Bacterial Agents
  • Azithromycin