Antihypertensive therapy versus alternative therapeutic options for prehypertension: an evidence-based approach

Future Cardiol. 2012 Jan;8(1):115-22. doi: 10.2217/fca.11.83.


The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) defines hypertension as systolic blood pressure (BP) ≥140 mmHg or diastolic BP ≥90 mmHg. The JNC-7 defines 'prehypertension' to include systolic BP values between 120 and 139 mmHg and diastolic BP values between 80 and 89 mmHg. Individuals with blood pressure in the prehypertension range are clearly at increased risk of developing hypertension in the future and have an increased risk of cardiovascular morbidity and mortality, compared with those with normal BP. However, there is paucity of evidence to intervene in these patients. In this article we discuss an evidence-based approach to therapeutic options in patients with prehypertension.

Publication types

  • Review

MeSH terms

  • Antihypertensive Agents / therapeutic use*
  • Blood Pressure
  • Diastole
  • Diet
  • Disease Progression
  • Evidence-Based Medicine*
  • Humans
  • Hypertension / classification
  • Hypertension / drug therapy*
  • Hypertension / epidemiology
  • Hypertension / prevention & control
  • Nutritional Status
  • Prehypertension / classification
  • Prehypertension / drug therapy*
  • Prehypertension / epidemiology
  • Primary Prevention
  • Risk Factors
  • Systole
  • United States / epidemiology


  • Antihypertensive Agents